The new Simpsons game is coming out soon (Ships 11/13/07). It looks great. As mentioned by Scott Amos in the video below, the game was made to look more like the TV animation than previous Simpsons games.
After watching the video, I definitely like the game. It looks like they are using the same game engine that is in Lego Star Wars and Star Wars II. The game is appealing and I am looking forward to its release.